Coordination is a system, not one organ acting alone
A stimulus is a detectable change. A receptor detects it. A coordinating centre processes information, and an effector such as a muscle or gland produces the response. The nervous system sends fast electrical impulses along neurons; the endocrine system releases hormones that travel in blood and usually act more slowly but for longer.
Negative feedback
Many internal variables fluctuate around a normal range. If a variable moves too far from that range, a corrective response opposes the change. As the variable returns toward range, the corrective signal reduces. This is negative feedback.